STUDIES ON HAPTOGLOBIN
نویسندگان
چکیده
منابع مشابه
Immunological and Biochemical Studies on Serum Haptoglobin
Antibody to purified type 1-1 human serum haptoglobin was obtained in rabbits. Using this antiserum it was demonstrated that the antigenic determinants of the haptoglobin molecule reside in both alpha- and beta-chains. No immunological difference between the normal alpha(1F)- and alpha(1S)-chains of haptoglobin could be detected. A number of healthy individuals whose haptoglobin pattern appeare...
متن کاملStudies on the serum haptoglobin level in hemoglobinemia and its influence on renal excretion of hemoglobin.
JAYLI:’ foiiiid that oti addition of a si ttI1 ai ount of hen og1ohin, rtiin shows weak peroxidase a(tivity with au optiintii around pH 4.4 in sJ)itP of the fact that no 50(11 a(1ivitv ean })e dei oiistiated in either suI)stan(e hv itS( 1f. In later investigations iii association with POlOliOVski he (lemonstrated that a complex l)et\VN9I hemoglobin (Jib) an(l a serum protein is responsible for ...
متن کاملHaptoglobin Synthesis. I. in Vivo Studies of the Production of Haptoglobin, Fibrinogen, and Gamma-globulin by the Canine Liver.
Haptoglobin is an a2 plasma glycoprotein that forms a stable complex with hemoglobin (1-5). The complex is cleared from the plasma much more rapidly than free haptoglobin so that marked hypoor anhaptoglobinemia is a concomitant of hemolysis (6, 7). Since free hemoglobin passes readily into the urine, whereas the complex, perhaps owing to its much greater size, does not, haptoglobin may play a r...
متن کاملComparative Studies on the Physical Characteristics of the Heritable Haptoglobin Groups of Human Serum
Ultracentrifugal studies of the alpha(2)-proteins of normal human serum before and after the addition of hemoglobin have revealed three separate and clearly distinguishable patterns based on the three major serum haptoglobin groups. Isolation of the three haptoglobin hemoglobin complexes disclosed characteristic patterns for each group. The heterozygote was found to possess electrophoretic and ...
متن کاملMolecular Modeling of the Human Hemoglobin-Haptoglobin Complex Sheds Light on the Protective Mechanisms of Haptoglobin
Hemoglobin (Hb) plays a critical role in human physiological function by transporting O2. Hb is safe and inert within the confinement of the red blood cell but becomes reactive and toxic upon hemolysis. Haptoglobin (Hp) is an acute-phase serum protein that scavenges Hb and the resulting Hb-Hp complex is subjected to CD163-mediated endocytosis by macrophages. The interaction between Hb and Hp is...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 1963
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.52.896